atherosclerosis surrogate marker in diabetic patients

نویسندگان

seid kazem razavi ratki assistant professor of nuclear medicine, department of radiology, shahid sadoughi university of medical sciences, yazd, iran

mona kharaji department of radiology, shahid sadoughi university of medical sciences, yazd, iran

nasim namiranian assistant professor of community medicinet. diabetes research center, shahid sadoughi university of medical sciences, yazd, iran

mohammad sobhan ardekani department of radiology, shahid sadoughi university of medical sciences, yazd, iran

چکیده

objective: duplex ultrasonography is a non-invasive, non-expensive screening test for carotid disease. intima media thickness (imt) is appropriate for atherosclerosis process diagnosis. leukoaraisis (la) increase the risk of cerebrovascular accident (cva). la patients need preventive medication for cva. imt is a non-invasive diagnostic and prognostic test in la. the aim of this study was evaluate the carotid imt and la in diabetic patients as atherosclerosis surrogate marker. materials and methods: the case-control study was done on 100 diabetic patients and 100 controls. they were selected by simple sampling method in shaheed sadoughi mri unit. two groups member were matched by age and sex. the patient’s information (age, sex, weight, height, past medical history, smoking history, ischemic heart disease(ihd), cva and past medication) according the study checklist was collected. all statistical analysis was done by spss21. results totally 200 patients were studied, 102 in normal group and 98 in diabetic group. the mean age of patients was 64.39 (±9.12) and 47% participants were male. there were no statistical differences between hypertension and hyperlipidemia frequency in two groups (p-value>0.05). the mean of left cimt was 0.856 (±0.202) in normal and 0.962 (±171) in diabetics groups (p-value: 0.026). the mean of right cimt was 0.853 (±0.215) in normal and 0.973 (±188) in diabetics groups (p-value: 0.024). the la was significantly more prevalent in diabetic patients (p-value:0.001). conclusion: la increases the risk of cva and dementia. the la pathology is unknown. the epidemiological studies revealed the age, diabetes, smoking and atherosclerosis are related with la. our findings showed that cimt as an atherosclerosis marker was higher in la patients than control group.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Atherosclerosis Surrogate Marker in Diabetic Patients

Objective: Duplex ultrasonography is a non-invasive, non-expensive screening test for carotid disease. Intima media thickness (IMT) is appropriate for atherosclerosis process diagnosis. Leukoaraisis (LA) increase the risk of cerebrovascular accident (CVA). LA patients need preventive medication for CVA. IMT is a non-invasive diagnostic and prognostic test in LA. The aim of this study was evalua...

متن کامل

Basal C-peptide Level as a Surrogate Marker of Subclinical Atherosclerosis in Type 2 Diabetic Patients

BACKGROUND Recent studies have revealed that C-peptide induces smooth muscle cell proliferation and causes human atherosclerotic lesions in diabetic patients. The present study was designed to examine whether the basal C-peptide levels correlate with cardiovascular risk in type 2 diabetes mellitus (T2DM) patients. METHODS Data was obtained from 467 patients with T2DM from two institutions who...

متن کامل

Osteoprotegerin as a Marker of Atherosclerosis in Diabetic Patients

Atherosclerosis is the principal cause of cardiovascular disease (CVD) and has many risk factors, among which is diabetes. Osteoprotegerin (OPG) is a soluble glycoprotein, involved in bone metabolism. OPG is also found in other tissues, and studies have shown that it is expressed in vascular smooth muscle cells. OPG has been implicated in various inflammations and also has been linked to diabet...

متن کامل

Carotid Atherosclerosis as a Surrogate Maker of Cardiovascular Disease in Diabetic Patients

Many studies have shown that carotid intima-media thickness (IMT) is associated with cardiovascular disease (CVD). Although it remains inconclusive whether assessment of carotid IMT is useful as a screening test for CVD in Japanese diabetic patients, a total of 271 patients (151 men aged 66 ± 10 (standard deviation) years and 220 women aged 71 ± 8 years) were divided into two groups based on th...

متن کامل

Tryptophan as a surrogate prognostic marker for diabetic nephropathy

AIMS/INTRODUCTION Diabetic nephropathy is one of the leading causes of end-stage renal disease. Unfortunately, reliable surrogate markers for predicting the prognostic outcome of diabetic nephropathy are as yet absent. In order to find new markers in predicting the progression of diabetic nephropathy, we carried out a prospective study by investigating the correlation between serum metabolites ...

متن کامل

Osteoprotegerin as a marker of atherosclerosis in type 1 and type 2 diabetic patients.

BACKGROUND/AIM The aim of this study was to investigate the availability of osteoprotegerin (OPG) as a marker of atherosclerosis and compare serum OPG levels with ankle-brachial index (ABI) in diabetic patients. MATERIALS AND METHODS A total of 31 type 1 and 31 type 2 diabetic patients without macrovascular complications and 20 healthy volunteers were included. Serum OPG levels and ABI were m...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
iranian journal of diabetes and obesity

جلد ۸، شماره ۲، صفحات ۸۵-۸۹

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023